Anti-inflammatory properties of methanolic extract of "sikari laharo" (Periploca calophylla) / J. Adhikari in Journal of Agriculture and Forestry University, Volume 4 (2020)  

Public ISBD [article]  inJournal of Agriculture and Forestry University > Volume 4 (2020) . - 231-242 p. Title : Anti-inflammatory properties of methanolic extract of "sikari laharo" (Periploca calophylla) Material Type: printed text Authors: J. Adhikari, Author ; S. Thapaliya, Author ; S. Singh, Author ; M. K. Shah, Author ; Nirmal Paudyal, Author Publication Date: 2020 Article on page: 231-242 p. Languages : English (eng) Keywords: Periploca calophylla, phyto-extract, inflammation, and animal model. Abstract: Inflammation, orchestrated in a series of cardinal signs is a pathophysiological condition that occurs during various clinical presentations. Periploca calophylla is a herbal plant which is used traditionally as an anti-inflammatory agent for a myriad of malaises in Nepalese countryside. The scientific research on the anti-inflammatory property of this plant is scanty, and if available elsewhere, its properties are not proven scientifically, except sporadic empirical evidence reported by the traditional faith healers. The main objective of this research was to establish a proof of concept on the anti-inflammatory property of P. calophylla based on the results obtained from a scientific experiment. Accordingly, Adult albino mice animal model was used for in vivo assessment of its property. Three different doses of 80% methanolic extract of the vine of P. calophylla (1.5 mg/ kg, 2 mg/kg, and 2.5 mg/kg) were administered intra-peritoneally to the animals of the test groups. Indomethacin (25 mg/ kg) and distilled water (3 mL/kg) were used as positive and negative controls, via the same route of administration. The antiinflammatory property was evaluated by the Carrageenan-induced hind paw oedema model test, fresh egg albumin induced paw oedema test, formalin-induced paw oedema test, and haematology. Extract of P. calophylla (1.5 mg/kg) significantly (p indicated that the phyto-extract of P. calophylla possessed a significant amount of anti-inflammatory property. This justifies the empirical and traditional use of this plant as an anti-inflammatory agent. Isolation of the particular compound related to this property needs further experimentation and scientific investigatio Link for e-copy: https://afu.edu.np/sites/default/files/Anti-inflammatory%20properties%20of%20met [...] [article] Anti-inflammatory properties of methanolic extract of "sikari laharo" (Periploca calophylla) [printed text] / J. Adhikari, Author ; S. Thapaliya, Author ; S. Singh, Author ; M. K. Shah, Author ; Nirmal Paudyal, Author . - 2020 . - 231-242 p. Languages : English (eng) in Journal of Agriculture and Forestry University > Volume 4 (2020) . - 231-242 p. Keywords: Periploca calophylla, phyto-extract, inflammation, and animal model. Abstract: Inflammation, orchestrated in a series of cardinal signs is a pathophysiological condition that occurs during various clinical presentations. Periploca calophylla is a herbal plant which is used traditionally as an anti-inflammatory agent for a myriad of malaises in Nepalese countryside. The scientific research on the anti-inflammatory property of this plant is scanty, and if available elsewhere, its properties are not proven scientifically, except sporadic empirical evidence reported by the traditional faith healers. The main objective of this research was to establish a proof of concept on the anti-inflammatory property of P. calophylla based on the results obtained from a scientific experiment. Accordingly, Adult albino mice animal model was used for in vivo assessment of its property. Three different doses of 80% methanolic extract of the vine of P. calophylla (1.5 mg/ kg, 2 mg/kg, and 2.5 mg/kg) were administered intra-peritoneally to the animals of the test groups. Indomethacin (25 mg/ kg) and distilled water (3 mL/kg) were used as positive and negative controls, via the same route of administration. The antiinflammatory property was evaluated by the Carrageenan-induced hind paw oedema model test, fresh egg albumin induced paw oedema test, formalin-induced paw oedema test, and haematology. Extract of P. calophylla (1.5 mg/kg) significantly (p indicated that the phyto-extract of P. calophylla possessed a significant amount of anti-inflammatory property. This justifies the empirical and traditional use of this plant as an anti-inflammatory agent. Isolation of the particular compound related to this property needs further experimentation and scientific investigatio Link for e-copy: https://afu.edu.np/sites/default/files/Anti-inflammatory%20properties%20of%20met [...]

Current practices of Nepalese veterinarians for the clinical management of pain in animals / S. Shrestha in Journal of Agriculture and Forestry University, Volume 4 (2020)  

Public ISBD [article]  inJournal of Agriculture and Forestry University > Volume 4 (2020) . - 225-230 p. Title : Current practices of Nepalese veterinarians for the clinical management of pain in animals Material Type: printed text Authors: S. Shrestha, Author ; M. K. Shah, Author Publication Date: 2020 Article on page: 225-230 p. Languages : English (eng) Keywords: Analgesic, assessment, surgery, animal birth control Abstract: The retrospective study was performed to know the trend of recent clinical practices for managing the post-surgical and nonsurgical pain in animals. The study included government hospitals, private clinics, organizations working on animal birth control program of Chitwan, Kathmandu, Lalitpur, and Kaski districts of Nepal. Overall, 1,177 and 1,084 animals received analgesics in 2017 and 2018, respectively. Categorically, 81% of cases underwent for soft tissue surgeries, and analgesics were prescribed variably for 1–5 days. However, 5% and 1% were orthopedic and ophthalmic cases that were treated with analgesics for 1–8 days. Remaining, 13% cases that were grouped into miscellaneous type received analgesics for 1–7 days For analgesia, meloxicam was the most preferred non-steroidal anti-inflammatory drug (98%) followed by tramadol (9%), and lignocaine-HCl (8%). Tramadol (9%) and lignocaine-HCl (8%) were prescribed particularly in severely traumatized cases whereas ketorolac (5%) were used in orthopedic cases. Only 18% veterinary patients received preemptive analgesics. Most of the hospitals, clinics and organizations did not perform pain scoring. Proper pain assessment and their scoring are imperative for prescribing the right analgesic for the effective treatment of pain in animals. Link for e-copy: https://afu.edu.np/sites/default/files/Current%20practices%20of%20Nepalese%20vet [...] [article] Current practices of Nepalese veterinarians for the clinical management of pain in animals [printed text] / S. Shrestha, Author ; M. K. Shah, Author . - 2020 . - 225-230 p. Languages : English (eng) in Journal of Agriculture and Forestry University > Volume 4 (2020) . - 225-230 p. Keywords: Analgesic, assessment, surgery, animal birth control Abstract: The retrospective study was performed to know the trend of recent clinical practices for managing the post-surgical and nonsurgical pain in animals. The study included government hospitals, private clinics, organizations working on animal birth control program of Chitwan, Kathmandu, Lalitpur, and Kaski districts of Nepal. Overall, 1,177 and 1,084 animals received analgesics in 2017 and 2018, respectively. Categorically, 81% of cases underwent for soft tissue surgeries, and analgesics were prescribed variably for 1–5 days. However, 5% and 1% were orthopedic and ophthalmic cases that were treated with analgesics for 1–8 days. Remaining, 13% cases that were grouped into miscellaneous type received analgesics for 1–7 days For analgesia, meloxicam was the most preferred non-steroidal anti-inflammatory drug (98%) followed by tramadol (9%), and lignocaine-HCl (8%). Tramadol (9%) and lignocaine-HCl (8%) were prescribed particularly in severely traumatized cases whereas ketorolac (5%) were used in orthopedic cases. Only 18% veterinary patients received preemptive analgesics. Most of the hospitals, clinics and organizations did not perform pain scoring. Proper pain assessment and their scoring are imperative for prescribing the right analgesic for the effective treatment of pain in animals. Link for e-copy: https://afu.edu.np/sites/default/files/Current%20practices%20of%20Nepalese%20vet [...]